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Rose Tyler, knighted Dame Rose of the Powell Estate, (TV: Tooth and Claw) was a companion of the Ninth Doctor and the first companion of the Tenth Doctor.
When the Doctor first met her in 2005, Rose was a nineteen-year-old living on a London council estate who had left school with little educational achievement.
Leaving herself a trail of clues throughout history, she was able to recognise, when all her hope had evaporated, that she needed to find her way back to the Doctor — even though he had abandoned her and the TARDIS together.
Without trying, she helped the Doctor work through some of the pain he had as the sole survivor of the Last Great Time War.
Indeed, when she met the Doctor, she was the girlfriend of Mickey Smith, but that relationship immediately began to decay after she started travelling in the TARDIS.
As Mickey himself noted, she transferred her romantic attention to the Doctor.
A major facet of her travels in the TARDIS was the fact that she had caused a temporal paradox by which she was the reason she became the so-called "Bad Wolf".
She thus became one of only three companions — along with Peri Brown and Wilfred Mott — to be the proximate cause of the Doctor's regeneration.
Forced to stop travelling with the Tenth Doctor because she was literally pulled into a different universe, she spent years trying to find a way back to the Doctor.